In prostate cancer radiotherapy, neighboring Organs at Risk (OAR) are irradiated leading to a risk of toxicity (i.e. Rectal bleeding in the case of the rectum in 10 % to 20% of cases). Sub-parts of the OAR should be spared during the therapy.
LTSI works have allowed the identification of these subregions likely involved in toxicity so that they can be spared during the radiotherapy planning.
The technology objective is to combine for the first time Dosimetric Factors (3D dose distributions) in these subregions with Radiobiological parameters based on genetics, in order to improve prediction which will allow to devise personalized treatments.
Graphic legend : a) Generic Sub-Region. Planned dose b) without and c) with constraints.
UMR_S 1099 - LTSI
IMPACT - Images and Models for the Planning and AssistanCe to surgery and Therapy
FR : FR1353552 - filed on the 04-18-2013
WO - EP,US