The molecular mechanisms responsible for airway smooth muscle cells (aSMC) contraction and proliferation in airway hyperresponsiveness (AHR) associated with asthma are still largely unknown. The small GTPases of the Rho family (RhoA, Rac1, and Cdc42) play a central role in SMC functions including migration, proliferation, and contraction.
We have identified the major role of RAC1 in aSMC contraction and its involment in AHR associated with allergic asthma. We have demonstrated that allergic asthma-associated excessive bronchoconstriction and AHR is dependent on RAC1 activity.
UMR 1087 - THORAX
Equipe III – Signalisation et physiopathologie vasculaire et pulmonaire
EP : EP17305662.3 - filed on the 06-06-2017
WO - CA,EP,JP,US